Diabetes Care | Don Valley Pharma

Diabetes Care

Other Diabetes Care Products

#BrandGeneric/CompositionPack Size
1Gliformin TabletsEach Tablet contains:
Metformin HCl………………………………500mg
Glibenclamide………………………………5mg
30's
2Metformina TabletsEach Tablet contains:
Metformin HCI………………………………500mg
50's
3Metformina TabletsEach Tablet contains:
Metformin HCI………………………………850mg
50's
4Metformina TabletsEach Tablet contains;
Metformin HCI……………………………..1gm
50's
5Novacyte Tablets 200mgEach Tablet contains:
Sotagliflozin………………………………...200mg
As per Requirement

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Antidiabetic Drugs

What is Diabetes mellitus (DM)

Diabetes mellitus (DM) it is a metabolic disorder characterized by hyperglycemia, glycosuria and ketonaemia.

Types of Diabetes Mellitus (DM)

Type I

Type me Insulin-dependent diabetes mellitus (IDDM) /juvenile onset diabetes mellitus:

  • There is β cell destruction in pancreatic islets; majority of cases are autoimmune (type 1A) antibodies that destroy β cells are detectable in blood.
  • In all type 1 cases circulating insulin levels are low and patients are more prone to ketosis.
  • This type is less common and has a low degree of genetic predisposition.

Type II

Type II Noninsulin-dependent diabetes mellitus (NIDDM)/maturity onset diabetes mellitus:

  • Has a high degree of genetic predisposition; generally has a late onset (past middle age). Over 90% cases of diabetes are type 2 DM.
  • Cause: Reduced sensitivity of peripheral tissues to insulin.

What are antidiabetic drugs?

Antidiabetic drugs are medicines developed to stabilize and control blood glucose levels amongst people with diabetes.

Why antidiabetic drugs are prescribed?

Antidiabetic drugs are commonly prescribed to manage diabetes.

There are a number of different types of antidiabetic drug including:

  • Insulin
  • Pramlintide (Amylin)
  • GLP-1 receptor agonists (such as Byetta and Victoza)
  • Oral hypoglycemics (tablets)

Leading Antidiabetic Drugs Manufacturer in Pakistan

Antidiabetic drugs for type 1 diabetes

For people with type 1 diabetes, daily insulin injections are essential to maintain health.

Type 1 diabetics must also eat properly, keep blood glucose levels from going too low or too high, and monitor blood sugar levels.

Antidiabetic drugs for type 2 diabetes

Oral hypoglycemic drugs are prescribed for the treatment of Type II diabetes.

These drugs lower blood glucose levels and are effective orally. The chief drawback of insulin is that it must be given by injection.

Types of Oral Hypoglycemic drugs

1- Sulfonylureas

Sulfonylureas provoke a brisk release of insulin from pancreas

  • First generation: Tolbutamide
  • Second generation: Glibenclamide, Glipizide,

2- Meglitinide analogues

They induce rapid onset short lasting insulin release

  • Repaglinide, Nateglinide

3- Glucagon-like peptide-1 (GLP-1) receptor agonists (Injectable drugs)

It induces insulin release from pancreatic β cells, inhibits glucagon release from α cells, slows gastric emptying and suppresses appetite

  • Exenatide, Liraglutide

4- Dipeptidyl peptidase-4 (DPP-4) inhibitors

DPP-4 in rapid degradation of endogenous GLP-1, orally active inhibitors of DPP-4 have been developed as indirectly acting insulin secretagogues.

  • Sitagliptin, Vildagliptin

5- Biguanide

Enhances insulin-mediated glucose uptake and disposal in skeletal muscle and fat.

  • Metformin

6- Thiazolidinediones (PPAR γ activator)

Glitazones tend to reverse insulin resistance by enhancing GLUT4 expression and translocation

  • Pioglitazone

7- α-Glucosidase inhibitors

They inhibits α-glucosidases, the final enzymes for the digestion of carbohydrates in the brush border of small intestine mucosa

  • Acarbose, Miglitol, Voglibose

8- Sodium-glucose cotransport-2 (SGLT-2)

They causes inhibition of SGLT-2 induces glucosuria and lowers blood glucose in type 2 DM, as well as causes weight loss.

  • Inhibitor: Dapagliflozin

Biguanides, such as Metformin, are commonly prescribed as a first antidiabetic medication. If biguanides are not effective on their own you may be given alternative medication either instead of, or in addition to, biguanides. The type of medication you are offered could depend on a variety of factors as different medication have different advantages and disadvantages.

Antidiabetic drugs available in Pakistan:

Metformina, Gliformin, Gliptin etc.