Diabetes Care

Diabetic care drugs are medications that help people with diabetes control their blood sugar levels and prevent serious complications such as heart disease, kidney failure, and nerve damage. Don Valley Pharma is leading diabetic care manufacturer drugs in Pakistan.

Other Diabetes Care Products

Sr. #	Brand Name/Form	Generic/Composition	Pack Size
1	Gliformin Tablets	Each Tablet contains: Metformin HCl………………………………………500mg Glibenclamide…………………………………………5mg	30's
2	Metformina Tablets	Each Tablet contains: Metformin HCI………………………………………500mg	50's
3	Metformina Tablets	Each Tablet contains: Metformin HCI………………………………………850mg	50's
4	Metformina Tablets	Each Tablet contains; Metformin HCI……………………………………..…..1gm	50's
5	Novacyte Tablets	Each Flim Coated Tablet contains; Sotagliflozin………………………………………....200mg	As per Requirement
6	Empadon Tablets	Each Flim Coated Tablet contains; Empagliflozin…………………………………………10mg	As per Requirement
7	Empadon Tablets	Each Flim Coated Tablet contains; Empagliflozin…………………………………………25mg	As per Requirement
8	Empadon Plus Tablets	Each Flim Coated Tablet contains; Empagliflozin………………………………….……12.5mg Metformin…………………………………………...500mg	As per Requirement
9	DV Gab Capsule 50mg	Each Capsule contains: Pregabalin….....................................................50mg	As per Requirement
10	DV Gab Capsule 75mg	Each Capsule contains: Pregabalin….....................................................75mg	As per Requirement
11	Olanzidon Tablet 10mg	Each Tablet contains: Olanzapine…......................................................10mg	As per Requirement
12	Olanzidon Tablet 5mg	Each Tablet contains: Olanzapine…......................................................5mg	As per Requirement
13	Proflozin Met Tablet	Each film coated tablet contains: Empagliflozin………………………………….…..12.5mg Metformin…………………………………………..500mg	As per Requirement
14	Proflozin Tablet 25mg	Each film coated tablet contains: Empagliflozin…………………………………………25mg	As per Requirement
15	SEIZ 200mg Tablets	Each film coated tablet contains: Sotagliflozin………………………………………....200mg	As per Requirement

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Antidiabetic Drugs

What is Diabetes mellitus (DM)

Diabetes mellitus (DM) it is a metabolic disorder characterized by hyperglycemia, glycosuria and ketonaemia.

Types of Diabetes Mellitus (DM)

Type I

Type me Insulin-dependent diabetes mellitus (IDDM) /juvenile onset diabetes mellitus:

There is β cell destruction in pancreatic islets; majority of cases are autoimmune (type 1A) antibodies that destroy β cells are detectable in blood.
In all type 1 cases circulating insulin levels are low and patients are more prone to ketosis.
This type is less common and has a low degree of genetic predisposition.

Type II

Type II Noninsulin-dependent diabetes mellitus (NIDDM)/maturity onset diabetes mellitus:

Has a high degree of genetic predisposition; generally has a late onset (past middle age). Over 90% cases of diabetes are type 2 DM.
Cause: Reduced sensitivity of peripheral tissues to insulin.

What are antidiabetic drugs?

Antidiabetic drugs are medicines developed to stabilize and control blood glucose levels amongst people with diabetes.

Why antidiabetic drugs are prescribed?

Antidiabetic drugs are commonly prescribed to manage diabetes.

There are a number of different types of antidiabetic drug including:

Insulin
Pramlintide (Amylin)
GLP-1 receptor agonists (such as Byetta and Victoza)
Oral hypoglycemics (tablets)

Leading Antidiabetic Drugs Manufacturer in Pakistan

Antidiabetic drugs for type 1 diabetes

For people with type 1 diabetes, daily insulin injections are essential to maintain health.

Type 1 diabetics must also eat properly, keep blood glucose levels from going too low or too high, and monitor blood sugar levels.

Antidiabetic drugs for type 2 diabetes

Oral hypoglycemic drugs are prescribed for the treatment of Type II diabetes.

These drugs lower blood glucose levels and are effective orally. The chief drawback of insulin is that it must be given by injection.

Types of Oral Hypoglycemic drugs

1- Sulfonylureas

Sulfonylureas provoke a brisk release of insulin from pancreas

First generation: Tolbutamide
Second generation: Glibenclamide, Glipizide,

2- Meglitinide analogues

They induce rapid onset short lasting insulin release

Repaglinide, Nateglinide

3- Glucagon-like peptide-1 (GLP-1) receptor agonists (Injectable drugs)

It induces insulin release from pancreatic β cells, inhibits glucagon release from α cells, slows gastric emptying and suppresses appetite

Exenatide, Liraglutide

4- Dipeptidyl peptidase-4 (DPP-4) inhibitors

DPP-4 in rapid degradation of endogenous GLP-1, orally active inhibitors of DPP-4 have been developed as indirectly acting insulin secretagogues.

Sitagliptin, Vildagliptin

5- Biguanide

Enhances insulin-mediated glucose uptake and disposal in skeletal muscle and fat.

Metformin

6- Thiazolidinediones (PPAR γ activator)

Glitazones tend to reverse insulin resistance by enhancing GLUT4 expression and translocation

Pioglitazone

7- α-Glucosidase inhibitors

They inhibits α-glucosidases, the final enzymes for the digestion of carbohydrates in the brush border of small intestine mucosa

Acarbose, Miglitol, Voglibose

8- Sodium-glucose cotransport-2 (SGLT-2)

They causes inhibition of SGLT-2 induces glucosuria and lowers blood glucose in type 2 DM, as well as causes weight loss.

Inhibitor: Dapagliflozin

Biguanides, such as Metformin, are commonly prescribed as a first antidiabetic medication. If biguanides are not effective on their own you may be given alternative medication either instead of, or in addition to, biguanides. The type of medication you are offered could depend on a variety of factors as different medication have different advantages and disadvantages.

Antidiabetic drugs available in Pakistan:

Metformina, Gliformin, Gliptin etc.