Haematinics | Don Valley Pharma

Haematinics

Other Haematinics Products

#BrandGeneric/CompositionPack Size
1Ferimoz TabletsEach Tablet contains:
Iron (III) Hydroxide Polymaltose Complex…….100mg
Folic Acid………………………………..………..0.35mg
10's
2Ferimoz SyrupEach 5mL contains:
Iron (III) Hydroxide Polymaltose Complex……..50mg
Folic Acid………………………………...………0.35mg
60mL
3Ferital SyrupEach 15mL contains:
Iron Protein Succinylate……........800mg eg to 40mg
60mL & 120mL

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Haematinics

What are Haematinic?

These are substances required for the formation of blood and are used for the treatment of anaemias.

Anaemia occurs when the balance between production and destruction of RBCs is disturbed by:

  1. Blood loss (acute or chronic)
  2. Impaired red cell formation due to:
    1. Deficiency of essential factors, i.e. iron, vitamin B12 & folic acid.
    2. Bone marrow depression (Hypoplastic Anaemia), erythropoietin deficiency. Iron
  3. Increased destruction of RBCs (Haemolytic Anaemia)

Iron is an essential mineral that is required for human life. Much of the iron in the body is found in red blood cells.

ANAEMIA Types:

  • Normocytic, Normochromic Anaemia
    • Acute blood loss
  • Microcytic, Hypochromic Anaemia
    • Iron deficiency anaemia, thalessimia
  • Macrocytic Anaemia
    • Vit B12 deficiency, folic acid deficiency
  • Pernicious Anaemia
    • Vit B12 deficiency
  • Hemolytic Anaemia
    • Destruction of RBC
  • Sickle Cell Anaemia
    • Sickle shaped RBC
  • Aplastic anaemia
    • Bone marrow disorder

Distribution of iron in body:

Haemoglobin – 66%

  • Iron stores as ferritin & haemosiderin – 25%
  • Myoglobin – 3

Best Iron Deficiency Drugs in Pakistan

It is an essential body constituent. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletion of iron stores may result in iron deficiency anemia. Iron is used to build up the blood in anemia. Total body iron in an adult is 2.5–5 g. It is more in men (50 mg/kg) than in women (38 mg/kg). It is distributed into:

  • Haemoglobin (Hb): 66%
  • Iron stores as ferritin and haemosiderin: 25%
  • Myoglobin (in muscles): 3%
  • Parenchymal iron (in enzymes, etc.): 6%

Daily Requirement

  • Adult male: 0.5–1 mg (13 μg/kg)
  • Adult female: 1–2 mg (21 μg/kg) (menstruating)
  • Infants: 60 μg/kg
  • Children: 25 μg/kg
  • Pregnancy: 3–5 mg (80 μg/kg) (last 2 trimesters)

Dietary Sources of Iron

  • Rich: Liver, egg yolk, oyster, dry beans, dry fruits, wheat germ, yeast.
  • Medium: Meat, chicken, fish, spinach, banana, apple.
  • Poor: Milk and its products, root vegetables.

Haemoglobin is a protoporphyrin; each molecule having 4 iron containing haeme residues. It has 0.33% iron; thus loss of 100 ml of blood (containing 15 g Hb) means loss of 50 mg elemental iron. To raise the Hb level of blood by 1 g/dl—about 200 mg of iron is needed. Iron is stored only in ferric form, in combination with a large protein apoferritin.

Iron is found in two forms:

  • Heme Iron: Meat, Myoglobin
  • Non-Heme Iron: Cereals, Fruits, Legumes

Vitamin C increases absorption of Non-Heme Iron – Iron is absorbed via two mechanisms:

  1. active transport of ferrous iron and;
  2. absorption of iron complexed with haem

Absorption of IRON

MOA:

Iron is important component of hemoglobin that carries oxygenated blood from lungs to different body parts. It also acts as catalyst for many metabolic reactions essential for cell growth. It maintains a healthy immune system & aids in energy production. It is transported inside mucosal cell by DMT1 & across basolateral membrane BY FP1 transporter protein. Iron released into plasma binds to transferrin & transported to different cells.

Indication:

  • Dietary Iron deficiency
  • Pregnancy
  • Premature babies
  • Malabsorption
  • Haemodialysis
  • Anaemia

Oral iron

  • The preferred route of iron administration is oral.
  • Ferrous sulfate: (hydrated salt 20% iron, dried salt 32% iron)
  • Ferrous gluconate (12% iron)
  • Ferrous fumarate (33% iron)
  • Dose: 200 mg elemental iron (infants and children 3–5 mg/kg) TDS Absorption is much better in empty stomach.

A/E: Gastric Irritation, Constipation, Staining of teeth, Metallic taste

Parenteral iron

  1. Iron therapy by injection is indicated only when:
    1. Oral iron is not tolerated: bowel upset is too much.
    2. Failure to absorb oral iron: inflammatory bowel disease.
    3. Non-compliance to oral iron.
    4. In presence of severe deficiency with chronic bleeding.
    5. Along with erythropoietin.
      1. Iron Dextran
      2. Iron Sucrose

DOSE: 75mg i.m (Max 100mg i.m.)

Best Folic Acid Brand in Pakistan

VITAMIN B9 (FOLIC ACID)

  • It occurs as yellow crystals which are insoluble in water, but its sodium salt is freely water soluble.
  • Chemically it is Pteroyl glutamic acid (PGA) consisting of pteridine + paraaminobenzoic acid (PABA) + glutamic acid.

MOA:

Folic acid is a precursor needed to make, repair, and methylate DNA; a cofactor in cell division and growth, such as in infancy and pregnancy.

  • Folate is itself inactive. After absorption it is converted into the active coenzyme, tetra hydro folic acid, essential for amino acid and DNA biosynthesis and cell division.

Folate deficiency occurs due to:

  1. Inadequate dietary intake
  2. Malabsorption: especially involving upper intestine—coeliac disease, tropical sprue, regional ileitis, etc.
  3. Biliary fistula; bile containing folate for recirculation is drained.
  4. Chronic alcoholism: intake of folate is generally poor.
  5. Increased demand: pregnancy, lactation, rapid growth periods, haemolytic anaemia and other diseases.
  6. Drug induced: prolonged therapy with anticonvulsants (phenytoin, phenobarbitone, and primidone) and oral contraceptives— interfere with absorption and storage of folate.

Sources: yeast , liver , green vegetables, fruits , nuts and cereals

Daily Requirements:

  • Adult: 50 mcg / day
  • Pregnant women: 100-200 mcg / day
  • Lactating women: 100-200 mcg / day

Dose: Therapeutic 2 to 5 mg/day, prophylactic 0.5 mg/day.

Indications:

  1. Treat megaloblastic anemia due to folate deficiency
  2. Pregnant women
  3. Premature infants
  4. Patients with hemolytic anemia
  5. Methotrexate toxicity
  6. Citrovorum factor rescue
  7. Enhance anticancer efficacy of 5-fluorouracil
  8. With anticonvulsant drugs

Our Products:

Ferital Syrup, Ferimoz Tablets, Ferimoz Syrup